IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study.
Identifieur interne : 001764 ( Main/Exploration ); précédent : 001763; suivant : 001765IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study.
Auteurs : Sarah Shalhoub [Oman] ; Fayssal Farahat [Arabie saoudite] ; Abdullah Al-Jiffri [Arabie saoudite] ; Raed Simhairi [Arabie saoudite] ; Omar Shamma [Arabie saoudite] ; Nauman Siddiqi [Arabie saoudite] ; Adnan Mushtaq [Arabie saoudite]Source :
- The Journal of antimicrobial chemotherapy [ 1460-2091 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antiviraux (administration et posologie), Association de médicaments (), Charge virale, Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Femelle, Humains, Infections à coronavirus (traitement médicamenteux), Interféron alpha (administration et posologie), Interféron bêta (administration et posologie), Mâle, Plasma sanguin (virologie), Pneumopathie virale (traitement médicamenteux), Poumon (virologie), Ribavirine (administration et posologie), Réaction de polymérisation en chaine en temps réel, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.
- MESH :
- administration et posologie : Antiviraux, Interféron alpha, Interféron bêta, Ribavirine.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- virologie : Plasma sanguin, Poumon.
- Adulte, Adulte d'âge moyen, Association de médicaments, Charge virale, Femelle, Humains, Mâle, Réaction de polymérisation en chaine en temps réel, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antiviral Agents (administration & dosage), Coronavirus Infections (drug therapy), Drug Therapy, Combination (methods), Female, Humans, Interferon-alpha (administration & dosage), Interferon-beta (administration & dosage), Lung (virology), Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Plasma (virology), Pneumonia, Viral (drug therapy), Real-Time Polymerase Chain Reaction, Retrospective Studies, Ribavirin (administration & dosage), Treatment Outcome, Viral Load.
- MESH :
- chemical , administration & dosage : Antiviral Agents, Interferon-alpha, Interferon-beta, Ribavirin.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- methods : Drug Therapy, Combination.
- virology : Lung, Plasma.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Real-Time Polymerase Chain Reaction, Retrospective Studies, Treatment Outcome, Viral Load.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with significant mortality. We examined the utility of plasma MERS-CoV PCR as a prognostic indicator and compared the efficacies of IFN-α2a and IFN-β1a when combined with ribavirin in reducing MERS-CoV-related mortality rates.
DOI: 10.1093/jac/dkv085
PubMed: 25900158
Affiliations:
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Le document en format XML
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Coronavirus (isolation & purification)</term><term>Plasma (virology)</term><term>Pneumonia, Viral (drug therapy)</term><term>Real-Time Polymerase Chain Reaction</term><term>Retrospective Studies</term><term>Ribavirin (administration & dosage)</term><term>Treatment Outcome</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antiviraux (administration et posologie)</term><term>Association de médicaments ()</term><term>Charge virale</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Interféron alpha (administration et posologie)</term><term>Interféron bêta (administration et posologie)</term><term>Mâle</term><term>Plasma sanguin (virologie)</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Poumon (virologie)</term><term>Ribavirine (administration et posologie)</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term><term>Interferon-alpha</term><term>Interferon-beta</term><term>Ribavirin</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term><term>Interféron alpha</term><term>Interféron bêta</term><term>Ribavirine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Therapy, Combination</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Plasma sanguin</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term><term>Plasma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Real-Time Polymerase Chain Reaction</term><term>Retrospective Studies</term><term>Treatment Outcome</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Charge virale</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with significant mortality. We examined the utility of plasma MERS-CoV PCR as a prognostic indicator and compared the efficacies of IFN-α2a and IFN-β1a when combined with ribavirin in reducing MERS-CoV-related mortality rates.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Oman</li></country></list><tree><country name="Oman"><noRegion><name sortKey="Shalhoub, Sarah" sort="Shalhoub, Sarah" uniqKey="Shalhoub S" first="Sarah" last="Shalhoub">Sarah Shalhoub</name></noRegion></country><country name="Arabie saoudite"><noRegion><name sortKey="Farahat, Fayssal" sort="Farahat, Fayssal" uniqKey="Farahat F" first="Fayssal" last="Farahat">Fayssal Farahat</name></noRegion><name sortKey="Al Jiffri, Abdullah" sort="Al Jiffri, Abdullah" uniqKey="Al Jiffri A" first="Abdullah" last="Al-Jiffri">Abdullah Al-Jiffri</name><name sortKey="Mushtaq, Adnan" sort="Mushtaq, Adnan" uniqKey="Mushtaq A" first="Adnan" last="Mushtaq">Adnan Mushtaq</name><name sortKey="Shamma, Omar" sort="Shamma, Omar" uniqKey="Shamma O" first="Omar" last="Shamma">Omar Shamma</name><name sortKey="Siddiqi, Nauman" sort="Siddiqi, Nauman" uniqKey="Siddiqi N" first="Nauman" last="Siddiqi">Nauman Siddiqi</name><name sortKey="Simhairi, Raed" sort="Simhairi, Raed" uniqKey="Simhairi R" first="Raed" last="Simhairi">Raed Simhairi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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